The activities of the Valley were developed during the centuries around the enterprise and the craftworks ability of the valley-dwellers and the rich vegetation of the Valley: the massive presence of chestnut woods with the consequent production of the famous chestnuts from Chiusa represented for a long time an important maintenance source.

The breeding of sheep and bovines was very practised together with the development of the craftworks ability and activity, which has always represented a production characteristic of the Valley. In fact the valley-dwellers were carvers, basket makers, weavers of chair straw seats, woodcutters and carbuné, that is skilled charcoal burner constructors to transform the less fine wood in charcoal. Furthermore, the breeding of silkworms was very diffused among the women.

Between the end of the eighteenth-century and the beginning of the nineteenth-century the Valley had an industrial vocation and the presence of factories increased, among them some very important and famous ones like the Glass and Crystal Factory Organisation of Piedmont and the Ceramic factory and some minor ones, but always developed according to the present craftworks activities like spinning mills, lime furnaces, a factory for the extraction of tannin from the chestnut and one for skin tanning.

Nowadays a part of the activities of the valley-dwellers is linked to tourism, being developed due to the historical and cultural enhancement of Chiusa di Pesio and the nearby Carthusian Monastery, to the safeguarding of the natural inheritance and to a good accommodation system. Agriculture is concentrated in specialized and high earning cultivations (especially strawberries and raspberries) while the breeding produces excellent and famous cheese above all the raschera, the sola and the testun.